Histone deacetylase inhibitors preserve function in aging axons
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چکیده
منابع مشابه
Histone deacetylase inhibitors preserve function in aging axons.
Aging increases the vulnerability of aging white matter to ischemic injury. Histone deacetylase (HDAC) inhibitors preserve young adult white matter structure and function during ischemia by conserving ATP and reducing excitotoxicity. In isolated optic nerve from 12-month-old mice, deprived of oxygen and glucose, we show that pan- and Class I-specific HDAC inhibitors promote functional recovery ...
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متن کاملHistone deacetylase inhibitors preserve white matter structure and function during ischemia by conserving ATP and reducing excitotoxicity.
The importance of white matter (WM) injury to stroke pathology has been underestimated in experimental animal models and this may have contributed to the failure to translate potential therapeutics into the stroke clinic. Histone deacetylase (HDAC) inhibitors are neuroprotective and also promote neurogenesis. These properties make them ideal candidates for stroke therapy. In a pure WM tract (is...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2012
ISSN: 0022-3042
DOI: 10.1111/j.1471-4159.2012.07949.x